Nos publications

Le travail des chercheurs est évalué à travers la qualité de leurs publications scientifiques. Ces publications, parues dans des revues internationales telles que Nature, Nature Genetics, The Lancet, PLoS One, PLoS Medicine, Gut, le New England Journal of Medicine… témoignent de l’excellence de leur production. La bibliométrie, incluant une évaluation quantitative des facteurs d’impact dans des revues prestigieuses, reflète l’intérêt de la communauté scientifique pour ces découvertes, reprises et citées par d’autres chercheurs.

La bibliométrie permet d’évaluer l’activité de recherche en appliquant des méthodes statistiques aux publications scientifiques (bibliographie des articles, signatures des articles, mots-clés, auteurs, etc.). Elle peut servir à mesurer la production scientifique et la réputation d’un chercheur, d’un laboratoire, d’une institution, d’un pays ou encore d’un domaine de recherche.

2020

  • Strub T, Ballotti R, Bertolotto C. The “ART” of Epigenetics in Melanoma: From histone “Alterations, to Resistance and Therapies.” Theranostics. 2020;10(4):1777-1797. doi: 10.7150/thno.36218
  • Mathis T, Caujolle JP, Thariat J. Choroidal Metastasis From Melanoma Treated by Cyberknife Irradiation. JAMA Ophthalmol. 2020;138(1):e190388. doi: 10.1001/jamaophthalmol.2019.0388
  • Martel A, Baillif S, Nahon-Esteve S, Gastaud L, Bertolotto C, Roméo B, Mograbi B, Lassalle S, Hofman P. Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives. Cancers (Basel). 2020;12(11):3284. doi: 10.3390/cancers12113284
  • Lassalle S, Nahon-Esteve S, Frouin E, Boulagnon-Rombi C, Josselin N, Cassoux N, Barnhill R, Scheller B, Baillif S, Hofman P. PD-L1 Expression in 65 Conjunctival Melanomas and Its Association with Clinical Outcome. Int J Mol Sci. 2020;21(23):9147. doi: 10.3390/ijms21239147
  • Carle X, Gastaud L, Salleron J, Tardy MP, Caujolle JP, Thyss A, Thariat J, Chevallier P. Optimizing the treatment of liver metastases from uveal melanomas with transarterial chemoembolization using melphalan and calibrated microspheres. Bull Cancer. 2020;107(12):1274-1283. doi: 10.1016/j.bulcan.2020.09.010
  • Bellini L, Strub T, Habel N, Pandiani C, Marchetti S, Martel A, Baillif S, Bailly-Maitre B, Gual P, Ballotti R, Bertolotto C. Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells. Cell Death Discov. 2020;6:22. doi: 10.1038/s41420-020-0259-2

2021

  • Strub T, Martel A, Nahon-Esteve S, Baillif S, Ballotti R, Bertolotto C. Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology. Prog Retin Eye Res. 2021;85:100968. doi: 10.1016/j.preteyeres.2021.100968
  • Patton EE, Mueller KL, Adams DJ, Anandasabapathy N, Aplin AE, Bertolotto C, Bosenberg M, Ceol CJ, Burd CE, Chi P, Herlyn M, Holmen SL, Karreth FA, Kaufman CK, Khan S, Kobold S, Leucci E, Levy C, Lombard DB, Lund AW, Marie KL, Marine JC, Marais R, McMahon M, Robles-Espinoza CD, Ronai ZA, Samuels Y, Soengas MS, Villanueva J, Weeraratna AT, White RM, Yeh I, Zhu J, Zon LI, Hurlbert MS, Merlino G. Melanoma models for the next generation of therapies. Cancer Cell. 2021;39(5):610-631. doi: 10.1016/j.ccell.2021.01.011
  • Pandiani C, Strub T, Nottet N, Cheli Y, Gambi G, Bille K, Husser C, Dalmasso M, Béranger G, Lassalle S, Magnone V, Pédeutour F, Irondelle M, Maschi C, Nahon-Estève S, Martel A, Caujolle JP, Hofman P, LeBrigand K, Davidson I, Baillif S, Barbry P, Ballotti R, Bertolotto C. Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease. Cell Death Differ. 2021;28(6):1990-2000. doi: 10.1038/s41418-020-00730-7
  • Nahon-Estève S, Martel A, Maschi C, Baillif S, Lassalle S, Caujolle JP. Swept-Source and Spectral-Domain OCT Imaging of Conjunctival Tumors. Ophthalmology. 2021;128(6):947-950. doi: 10.1016/j.ophtha.2020.09.036
  • Nahon-Estève S, Bertolotto C, Picard-Gauci A, Gastaud L, Baillif S, Hofman P, Groulier A, Maschi C, Caujolle JP, Lassalle S, Martel A. Small but Challenging Conjunctival Melanoma: New Insights, Paradigms and Future Perspectives. Cancers (Basel). 2021;13(22):5691. doi: 10.3390/cancers13225691
  • Mathis T, Maschi C, Mosci C, Espensen CA, Rosier L, Favard C, Tick S, Remignon CH, Ligorio P, Bonin N, Gambrelle J, Nguyen AM, Faber C, Meyer L, Mouriaux F, Herault J, Baillif S, Kiilgaard JF, Kodjikian L, Caujolle JP, Salleron J, Thariat J. COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA. Retina. 2021;41(2):277-286. doi: 10.1097/IAE.0000000000002843
  • Martel A, Lassalle S, Picard-Gauci A, Gastaud L, Montaudie H, Bertolotto C, Nahon-Esteve S, Poissonnet G, Hofman P, Baillif S. New Targeted Therapies and Immunotherapies for Locally Advanced Periocular Malignant Tumours: Towards a New “Eye-Sparing” Paradigm? Cancers (Basel). 2021;13(11):2822. doi: 10.3390/cancers13112822
  • Martel A, Baillif S, Thomas P, Almairac F, Galatoire O, Hamedani M, Fontaine D, Lanteri-Minet M. Phantom eye pain: a multicentric study in 100 patients. Acta Ophthalmol. 2021;99(5):e753-e760. doi: 10.1111/aos.14657
  • Martel A, Baillif S, Nahon-Esteve S, Gastaud L, Bertolotto C, Lassalle S, Lagier J, Hamedani M, Poissonnet G. Orbital exenteration: an updated review with perspectives. Surv Ophthalmol. 2021;66(5):856-876. doi: 10.1016/j.survophthal.2021.01.008
  • Lamas NJ, Martel A, Nahon-Estève S, Goffinet S, Macocco A, Bertolotto C, Lassalle S, Hofman P. Prognostic Biomarkers in Uveal Melanoma: The Status Quo, Recent Advances and Future Directions. Cancers (Basel). 2021;14(1):96. doi: 10.3390/cancers14010096
  • Krossa I, Ballotti R, Bertolotto C. The ERK signaling pathway returns to the limelight in uveal melanomas. Pigment Cell Melanoma Re. 2021;34(5):832-833. doi: 10.1111/pcmr.12965
  • Jain P, Finger PT, Fili M, Damato B, Coupland SE, Heimann H, Kenawy N, J Brouwer N, Marinkovic M, Van Duinen SG, Caujolle JP, Maschi C, Seregard S, Pelayes D, Folgar M, Yousef YA, Krema H, Gallie B, Calle-Vasquez A, American Joint Committee on Cancer Ophthalmic Oncology Task Force. Conjunctival melanoma treatment outcomes in 288 patients: a multicentre international data-sharing study. Br J Ophthalmol. 2021;105(10):1358-1364. doi: 10.1136/bjophthalmol-2020-316293
  • Habel N, El-Hachem N, Soysouvanh F, Hadhiri-Bzioueche H, Giuliano S, Nguyen S, Horák P, Gay AS, Debayle D, Nottet N, Béranger G, Paillerets BB de, Bertolotto C, Ballotti R. FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells. Cell Death Differ. 2021;28(6):1837-1848. doi: 10.1038/s41418-020-00710-x
  • Espensen CA, Kiilgaard JF, Appelt AL, Fog LS, Herault J, Maschi C, Caujolle JP, Thariat J. Dose-Response and Normal Tissue Complication Probabilities after Proton Therapy for Choroidal Melanoma. Ophthalmology. 2021;128(1):152-161. doi: 10.1016/j.ophtha.2020.06.030
  • Chiabo J, Nahon-Esteve S, Alketbi M, Lassalle S, Tieulie N, Martel A. Orbital non-HIV immune reconstitution inflammatory syndrome after cytapheresis. Eur J Ophthalmol. 2021;31(3):NP85-NP88. doi: 10.1177/1120672120919339
  • Cheli Y, Tulic MK, El Hachem N, Nottet N, Jacquel A, Gesson M, Strub T, Bille K, Picard-Gauci A, Montaudié H, Beranger GE, Passeron T, Close P, Bertolotto C, Ballotti R. ITGBL1 is a new immunomodulator that favors development of melanoma tumors by inhibiting natural killer cells cytotoxicity. Mol Cancer. 2021;20(1):12. doi: 10.1186/s12943-020-01306-2
  • Bertolotto C. Cutaneous and uveal melanoma: two different cancers in therapeutic needs. C R Biol. 2021;344(3):219-231. doi: 10.5802/crbiol.63

2022

  • Thariat J, Martel A, Matet A, Loria O, Kodjikian L, Nguyen AM, Rosier L, Herault J, Nahon-Estève S, Mathis T. Non-Cancer Effects following Ionizing Irradiation Involving the Eye and Orbit. Cancers (Basel). 2022;14(5):1194. doi: 10.3390/cancers14051194
  • Martel A, Baillif S, Thomas P, Almairac F, Galatoire O, Hamedani M, Fontaine D, Lanteri-Minet M. Phantom vision after eye removal: prevalence, features and related risk factors. Br J Ophthalmol. 2022;106(11):1603-1609. doi: 10.1136/bjophthalmol-2021-319091
  • Marin L, Toumi E, Caujolle JP, Doyen J, Martel A, Nahon-Esteve S, Maschi C, Baillif S. OCT-angiography for the diagnosis of radiation maculopathy in patients treated with proton beam therapy: A 2-year prospective study. Eur J Ophthalmol. 2022;32(5):3035-3042. doi: 10.1177/11206721211067331
  • Long-Mira E, Picard-Gauci A, Lassalle S, Hofman V, Lalvée S, Tanga V, Zahaf K, Bonnetaud C, Lespinet V, Camuzard O, Montaudié H, Poissonnet G, Passeron T, Ilié M, Hofman P. Comparison of Two Rapid Assays for the Detection of BRAF V600 Mutations in Metastatic Melanoma including Positive Sentinel Lymph Nodes. Diagnostics (Basel). 2022;12(3):751. doi: 10.3390/diagnostics12030751
  • Krossa I, Strub T, Martel A, Nahon-Esteve S, Lassalle S, Hofman P, Baillif S, Ballotti R, Bertolotto C. Recent advances in understanding the role of HES6 in cancers. Theranostics. 2022;12(9):4374-4385. doi: 10.7150/thno.72966
  • Estrada C, Mirabal-Ortega L, Méry L, Dingli F, Besse L, Messaoudi C, Loew D, Pouponnot C, Bertolotto C, Eychène A, Druillennec S. MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells. Commun Biol. 2022;5(1):101. doi: 10.1038/s42003-022-03049-w

2023

  • Thariat J, Mathis T, Pace-Loscos T, Peyrichon ML, Maschi C, Rosier L, Nguyen M, Bonnin N, Aloi D, Gastaud L, Gaucher D, Caujolle JP, Château Y, Herault J. Single-Masked Randomized Phase 2 Study Assessing 2 Forms of Hypofractionated Proton Therapy in Patients With Large Choroidal Melanomas. Int J Radiat Oncol Biol Phys. 2023;117(2):357-369. doi: 10.1016/j.ijrobp.2023.04.028
  • Proteau S, Krossa I, Husser C, Guéguinou M, Sella F, Bille K, Irondelle M, Dalmasso M, Barouillet T, Cheli Y, Pisibon C, Arrighi N, Nahon-Estève S, Martel A, Gastaud L, Lassalle S, Mignen O, Brest P, Mazure NM, Bost F, Baillif S, Landreville S, Turcotte S, Hasson D, Carcamo S, Vandier C, Bernstein E, Yvan-Charvet L, Levesque MP, Ballotti R, Bertolotto C, Strub T. LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition. EMBO Mol Med. 2023;15(12):e17719. doi: 10.15252/emmm.202317719
  • Martel A, Gastaud L, Bonnetaud C, Nahon-Esteve S, Washetine K, Bordone O, Salah M, Tanga V, Fayada J, Lespinet V, Allegra M, Lalvee S, Zahaf K, Baillif S, Bertolotto C, Mograbi B, Lassalle S, Hofman P. Need for a Dedicated Ophthalmic Malignancy Clinico-Biological Biobank: The Nice Ocular MAlignancy (NOMA) Biobank. Cancers (Basel). 2023;15(8):2372. doi: 10.3390/cancers15082372
  • Lamas NJ, Lassalle S, Martel A, Nahon-Estève S, Macocco A, Zahaf K, Lalvee S, Fayada J, Lespinet-Fabre V, Bordone O, Pedeutour F, Baillif S, Hofman P. Characterisation of the protein expression of the emerging immunotherapy targets VISTA, LAG-3 and PRAME in primary uveal melanoma: insights from a southern French patient cohort. Pathology. 2023;55(7):929-944. doi: 10.1016/j.pathol.2023.08.003
  • Berico P, Nogaret M, Cigrang M, Lallement A, Vand-Rajabpour F, Flores-Yanke A, Gambi G, Davidson G, Seno L, Obid J, Vokshi BH, Le Gras S, Mengus G, Ye T, Cordero CF, Dalmasso M, Compe E, Bertolotto C, Hernando E, Davidson I, Coin F. Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability. Cell Rep. 2023;42(11):113363. doi: 10.1016/j.celrep.2023.113363

2024

  • Razlog E, Denoyer A, Baillif S, Arndt C, Dubernard X, Caujolle JP, Nahon-Esteve S, Martel A. Revisiting the Use of Deep Temporalis Fascia Grafts in Ophthalmology. Semin Ophthalmol. 2024;39(6):451-459. doi: 10.1080/08820538.2024.2346756
  • Piperno-Neumann S, Koning L de, Marchal T, Gastaud L, Waechter L, Fogliarini A, Bouleuc C, Libert Y, Seban R, Thery L, Ducoulombier A, Rodrigues M, Bredart A, Savignoni A, Dolbeault S, Burnod A. Early palliative care in metastatic uveal melanoma (early together): protocol of a prospective randomized Phase III trial. Melanoma Manag. 2024;11(1):2382080. doi: 10.1080/20450885.2024.2382080
  • Nhari M, Nahon-Esteve S, Nguyen AM, Kodjikian L, Mathis T. Diagnosis of a uveal melanoma arising from the choroid beneath a congenital hypertrophy of the retinal pigment epithelium: the value of microvascular flow imaging. Can J Ophthalmol. 2024;59(5):e643-e646. doi: 10.1016/j.jcjo.2024.03.006
  • Nahon-Estève S, Orbach D, Le Loarer F, Hofman P, Lassalle S. Fibroblastic orbital tumour with NTRK1 fusion transcript: when TRK inhibitors rescue surgery. Can J Ophthalmol. 2024;59(4):e407-e409. doi: 10.1016/j.jcjo.2023.11.008
  • Mudhar HS, Krishna Y, Cross S, Auw-Haedrich C, Barnhill R, Cherepanoff S, Eagle R, Farmer J, Folberg R, Grossniklaus H, Herwig-Carl MC, Hyrcza M, Lassalle S, Loeffler KU, Moulin A, Milman T, Verdijk RM, Heegaard S, Coupland SE. A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance. Lab Invest. 2024;104(1):100281. doi: 10.1016/j.labinv.2023.100281
  • Meierjohann S, Bertolotto C. Messing with cancer therapy: how the melanoma phenotype predicts checkpoint inhibitor response. Signal Transduct Target Ther. 2024;9(1):76. doi: 10.1038/s41392-024-01785-5
  • Di Leo L, Pagliuca C, Kishk A, Rizza S, Tsiavou C, Pecorari C, Dahl C, Pacheco MP, Tholstrup R, Brewer JR, Berico P, Hernando E, Cecconi F, Ballotti R, Bertolotto C, Filomeni G, Gjerstorff MF, Sauter T, Lovat P, Guldberg P, De Zio D. AMBRA1 levels predict resistance to MAPK inhibitors in melanoma. Proc Natl Acad Sci U S A. 2024;121(25):e2400566121. doi: 10.1073/pnas.2400566121
  • Bertolotto C. Mechanisms of melanoma aggressiveness with age. Nat Aging. 2024;4(3):287-288. doi:10.1038/s43587-024-00574-7

2025

  • Seedor RS, Aplin AE, Bertolotto C, Carvajal RD, Deacon N, Doble K, Hamid O, Haq R, Kadosh M, Khan S, Kraska J, Lutzky J, McKean M, Montazeri K, Moser J, Onken M, Orloff M, Sacco JJ, Smalley K, Selig SM. Meeting Report From the 2023 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Philadelphia, PA, November 2023. Pigment Cell Melanoma Res. 2025;38(1):e13205. doi: 10.1111/pcmr.13205
  • Rodrigues M, Servois V, Mariani P, Pracht M, Dutriaux C, Grillet F, Ryckwaert T, Ducoulombier A, Neidhardt EM, Piperno-Neumann S. Management of metastatic uveal melanoma: French expert consensus guidelines. Bull Cancer. Published online July 7, 2025:S0007-4551(25)00274-7. doi: 10.1016/j.bulcan.2025.05.011
  • Restivo L, Rochigneux P, Bouhnik AD, Arciszewski T, Bourmaud A, Capodano G, Ducoulombier A, Mancini J, Duffaud F, Gonçalves A, Apostolidis T, Proux A. Patients’ psychosocial attributes and aggressiveness of cancer treatments near the end of life. Oncologist. 2025;30(2):oyae317. doi: 10.1093/oncolo/oyae317
  • Jain P, Finger PT, Filì M, Damato B, Coupland SE, Heimann H, Kenawy N, Brouwer NJ, Marinkovic M, van Duinen S, Caujolle JP, Maschi C, Seregard S, Pelayes DE, Folgar M, Yousef Y, Krema H, Gallie B, Calle Vasquez CA, American Joint Committee on Cancer Ophthalmic Oncology Task Force. Metastatic conjunctival melanoma: a multicentre international study. Br J Ophthalmol. 2025;109(6):652-659. doi: 10.1136/bjo-2024-326043
  • Hamerstehl A, Gadiollet É, Martel A, Groulier A, Aloi D, Nguyen AM, Lassalle S, Bertolotto C, Caujolle JP, Maschi C, Ducoulombier A, Mathis T, Baillif S, Nahon-Estève S. Impact of COVID-19 on uveal melanoma in France. J Fr Ophtalmol. 2025;48(1):104351. doi: 10.1016/j.jfo.2024.104351
  • Gaudel C, Pisibon C, Soysouvanh F, Giuliano S, Picard-Gauci A, Leclerc J, Hofman P, Bahadoran P, Bertolotto C, Ballotti R. Loss of LYN Is Frequent in Targeted Therapy-Resistant Melanoma Cells and Favors Metastatic Properties. J Invest Dermatol. 2025;145(1):214-218.e5. doi: 10.1016/j.jid.2024.06.1286
  • Fricker J, Nahon-Esteve S, Tick S, Nhari M, Chotard G, Nguyen AM, Baillif S, Kodjikian L, Mathis T. Radiation-induced maculopathy and fluocinolone acetonide implant. Graefes Arch Clin Exp Ophthalmol. Published online August 14, 2025. doi: 10.1007/s00417-025-06916-4
  • Dupré E, Guiho A, Beauvais T, Labous L, Cardon T, Bertolotto C, Khammari A, Quéreux G, Salzet M, Labarrière N, Rabu C, Lang F. Systematic identification of lincRNA-derived immunogenic peptides in melanoma. Oncoimmunology. 2025;14(1):2538684. doi: 10.1080/2162402X.2025.2538684
  • Dubar P, Mathis T, Hucteau E, Thariat J, Nhari M, Maschi C, Faber C, Kiilgaard JF, Mosci C, Favard C, Tick S, Nguyen AM, Caujolle JP, Delyfer MN, Rosier L. A fast protocol for photodynamic therapy in exudative choroidal circumscribed hemangioma: Early laser irradiance after end of verteporfin infusion. Acta Ophthalmol. Published online May 5, 2025. doi: 10.1111/aos.17513